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Dual-Agonist Comparisons Tirzepatide (found in medications like Mounjaro) targets two receptors: GLP-1 and GIP

Combining medications requires careful evaluation of interactions and safety, especially if considering other appetite suppressants or off-label therapies

However, significant weight loss may alter levothyroxine requirements, and Wegovy's effect on gastric emptying could potentially influence absorption of oral medications, so thyroid function should be monitored regularly

However, according to the Gov.uk MHRA guidelines, Rybelsus is exclusively licensed for the treatment of Type 2 diabetes