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In this study, we demonstrated that GSSG accumulation induced by either H 2 O 2 exposure or GR inhibition suppressed TNF-induced NF-B activation

Altered regulation of the HPA axis has been observed in PTSD pathology

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These results are supported by a recent randomized placebo controlled trial, which demonstrated that a 6-week sulforaphane intervention (30 mg/day) safely improved depressive symptoms, as measured by the Hamilton Rating Scale for Depression, in 66 participants with a history of a cardiac procedure and presence of mild to moderate depression (Ghazizadeh-Hashemi et al., 2021)