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2.8% for 16 months, and 1.4% for 18 months

Quick Answer: GLP-1 injections begin suppressing appetite within one to two weeks, with measurable weight loss starting by week four and hemoglobin A1c reductions evident after 12 to 16 weeks

Some patients find that lower doses (e.g., 1.7 mg) work well for sustaining results with fewer side effects

lifetime decreased medical expense $62K JAMA Health Forum (2025): Showed that the cost per quality adjusted life year (QALY) for tirzepatide (Zepbound) was $197K and the cost per QALY for semaglutide (Wegovy) was $468K

The following data are based on findings in studies performed with sitagliptin or metformin individually