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Our data indicate the catalytic Cys256 is needed for the auto-AcT activity, suggesting the lysine side chains must come into close spatial proximity to the active site in order to become acetylated

CoQ10 levels decrease with aging

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However, elucidation of the factors that underlie the sensitivity of a given cell type to ferroptosis 7 is crucial to understand the pathophysiological role of ferroptosis and how it may be exploited for the treatment of cancer