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Even with an active nomination, injectable GHK-Cu would face a tougher path through PCAC because the safety bar for an injectable is higher than for a cream

boulardii doesnt colonize the gut but does have beneficial antimicrobial and anti-inflammatory properties

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VKTX would be a speculative position within a portfolio with additional de-risking data required following additional trials (slower titration for improved tolerability and TEAEs, increasing efficacy over longer duration, maintenance ability) to possibly allow for a more generous sizing/position