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Efficacy and Mechanisms of Apoptosis Induction by Simultaneous Inhibition of PI3K with GDC-0941 and Blockade of Bcl-2 (ABT-737) or FLT3 (Sorafenib) In AML Cells In the Hypoxic bone Marrow Microenvironment

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However, these protective effects were attenuated when either LY294002 (a specific inhibitor of the PI3K/Akt/mTOR pathway) or anisomycin (an activator of the TLR4/p38/MAPK pathway) was administered