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If you are taking a GLP-1 medication and experience any of these symptoms for more than 24 hours, check in with your doctor

PMID 12082127

Lilly has agreed to pay up to $290 million in upfront, development and regulatory milestones to use Camurus long-acting delivery technology

Results: CagriSema: 23.0% average weight loss Tirzepatide: 25.5% average weight loss CagriSema did not meet the non-inferiority threshold tirzepatide won by 2.5 percentage points This is a meaningful result

consideration of dose escalation 6 months : Formal assessment of treatment efficacy according to appropriate criteria: For diabetes (NICE NG28): HbA1c reduction of at least 11 mmol/mol (1.0%) and weight loss of at least 3% For weight management: At least 5% weight loss from baseline on maintenance dose (per SmPC and NICE guidance) Annually thereafter : Ongoing monitoring of metabolic parameters, cardiovascular risk factors, and treatment appropriateness Treatment adjustments may be necessary if: Side effects remain intolerable despite supportive measures Weight loss plateaus before reaching target (may warrant dose increase if not at maximum) Inadequate glycaemic control persists (may require additional diabetes medications) Significant weight loss goals are achieved (maintenance strategies and potential dose reduction) Patients should maintain open communication with their healthcare team, reporting both positive developments and concerns