Realizing this potential requires addressing critical gaps: although preclinical studies highlight innovative mechanisms (e.g., multimodal therapies and stimuli-responsive release), robust clinical validation remains scarce, necessitating phase I/II trials to confirm efficacy and safety
113,114 Current treatments are only partially effective, and further understanding of the diseases mechanism are needed to develop effective drugs
Tendon BPC-157 on tendon injuries (rat Achilles models): shortening of healing time by 30-40%, partial restoration of collagen fiber organization, improvement of ultimate tensile strength
Future research will be needed to assess whether the new CBT for BED, which combines GLP-1RAs for a subset of patients, is more effective than existing psychological treatments for BED associated with obesity
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