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The compound's interaction with multiple pathways (hormonal, vascular, and neural) compounds the uncertainty of extended exposure
Farrell TW, Korniyenko A, Hu G, Fulmer T
Thus, to what extent we can fit theory to the data depends on the accuracy of not only the concentrations as a function of pH, but also on the accuracy of the measured solubility of the very low solubility Nic OH species and, if available, on measuring or calculating the pKa itself
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