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In particular, we focused on the p21 N-terminal cyclin-CDK binding domain, required for inhibition of G1/S cell cycle progression, and the C-terminal PCNA binding domain involved in suppressing DNA synthesis (Chen et al, 1995) (Fig 2D)

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Shared decision-making between the patient, GP, and specialist (rheumatologist, endocrinologist, gastroenterologist) ensures coordinated, safe care

Efficacy depends on delivery technology

As mentioned above, glutamine is imported by the SLC1A5 transporter, while leucine is taken up by the bidirectional antiporter SLC7A5, which exports glutamine to the outside of the cell