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As radial chromosomes in HR-defective cells arise from illegitimate rejoining of DSBs by NHEJ 32 , these observations implied that NHEJ is not affected by loss of PDS5B

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Besides, geniposide suppressed A accumulation and alleviated cognitive dysfunction in APP/PS1 mice, attenuated A-induced reduction of LTP in acute hippocampal slices, and attenuated A-induced synaptic dysfunction in cultured hippocampal neurons (221, 222)

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