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Mice expressing tau mutations such as P301L or P301S have been extensively used to investigate how tau aggregation leads to neuronal dysfunction, synaptic loss, and cognitive decline, recapitulating the tau pathology seen in AD patients 137

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A plateau frequently traces back to something the medication was never going to fix on its own

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Lefvre, C

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Nat Rev Neurosci 16(6):317331 Hao S et al (2019) The lateral hypothalamic and BNST GABAergic projections to the anterior ventrolateral periaqueductal gray regulate feeding

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