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Obesity For weight loss, healthcare professionals may prescribe GLP-1 agonists for people with an initial BMI of 30 or higher or people who have a BMI of 27 or higher and at least one weight-related health condition, such as: type 2 diabetes prediabetes high blood pressure high cholesterol heart disease nonalcoholic fatty liver disease obstructive sleep apnea polycystic ovary syndrome Typically, healthcare professionals only prescribe these medications after someone has tried other weight loss methods, such as diet and exercise, without success

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