BPC-157 is not a first-line treatment for most conditions
then a 20 mg/kg dose (the typical therapeutic dose) produces a gut concentration of 6000 M, assuming 75% bioavailability
In epileptic seizures, long-term seizures promote excessive ROS production and lead to the occurrence of oxidative stress, which is closely related to the generation of epileptic activities and the death of nerve cells ( FIGURE 2 Regulation of Ferroptosis by Cysteine-Glutathione (Cys-GSH) Redox Axis Previous studies have shown that oxidative stress causes ferroptosis (Shekh-Ahmad et al., 2019)
The availability of oral glutathione is negligible, so it must be biosynthesized from its constituent amino acids, cysteine, glycine and glutamic acid
Jamalpoor A, van Gelder CA, Yousef Yengej FA, Zaal EA, Berlingerio SP, Veys KR, Pou Casellas C, Voskuil K, Essa K, Ammerlaan CM, Rega LR, van der Welle RE, Lilien MR, Rookmaaker MB, Clevers H, Klumperman J, Levtchenko E, Berkers CR, Verhaar MC, Altelaar M, Masereeuw R, Janssen MJ (2021) Cysteamine-bicalutamide combination therapy corrects proximal tubule phenotype in cystinosis
