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Relation of elevated heart rate in patients with heart failure with reduced ejection fraction to one-year outcomes and costs

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This study further revealed that AS-IV can limit NF-B nuclear translocation in high-glucose-stimulated GMCs by upregulating Nrf2 and reducing ROS generation, subsequently downregulating inflammatory markers like MCP-1, TNF, IL-1, IL-6, and fibrosis markers Fn and Col IV downstream of NF-B, thereby ameliorating GMC inflammation and fibrotic damage under high glucose (Su et al., 2023)