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For diabetic retinopathy, GLP-1RAs are associated with the early worsening phenomenon linked to rapid glycemic control, a signal not typically observed with SGLT2 inhibitors, which generally show a neutral or modestly protective effect
However, three factors may explain this discrepancy
Microdosing may be particularly beneficial for women with PCOS, perimenopausal weight gain, or metabolic sluggishness
Limited recent data exist on prescribing patterns and patient characteristics for GLP-1 RA medications, whether used as anti-diabetic medication (ADM) for patients with type 2 diabetes (T2D) and/or used as an anti-obesity medication (AOM) for patients with overweight or obesity
A80-229AP, Bethyl Laboratories, Inc.), diluted in PBS/T/M (pH 5.5 or pH 7.4), was added for 1 h at room temperature, followed by a washing step and detection with 1 mg/mL (100 L/well) of p -Nitrophenyl Phosphate Substrate (Sigma-Aldrich) dissolved in diethanolamine buffer (pH 9.8) (Sigma-Aldrich)
