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A Paradigm Shift in Type 2 Diabetes Management (NICE NG28 Update, Feb 2026) The latest NICE guidelines published this week mark the biggest shake-up in T2DM care in a decade

In a randomized double-blind, placebo-controlled, phase 3 trial of adults with overweight or obesity without type 2 diabetes, estimated mean body weight change from baseline to weak 68 was 15.1% (SE 0.5) in the oral semaglutide group and 2.4% (0.5) in the placebo group [99]

A test for occult blood in the stool should be performed in all infants with constipation and in any child with constipation who has pain, failure to thrive, diarrhea, or a family history of colon cancer or polyps

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Individual responses vary, so a provider should determine which option fits your needs