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ROS generated after the formation of ceramide or after an increase in energy metabolism induced by several receptor-interacting protein kinases (RIPs), either in the mitochondrial ETC and/or by NOXs, have been reported to enhance necroptosis 123,124,125

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Reactive oxygen species: from tumorigenesis to therapeutic strategies in cancer

After PMA stimulation, treatment was performed with 100 ng ml 1 LPS (Sigma-Aldrich, L4391