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The ravagalimab Phase 2 single-arm study evaluated this anti-CD40 monoclonal antibody in moderate to severe UC patients by constructing synthetic placebo control groups using two approaches: first, a Bayesian method incorporating historical placebo data from meta-analyses of tofacitinib, ustekinumab, and upadacitinib pivotal trials, taking advantage of objective centrally-read endoscopies and low placebo endoscopic improvement rates

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a computational approach to identify sets of co-regulated genes associated with treatment outcomes) on bulk RNA-seq data was applied where groups of genes that move in the same direction between conditions are packed into modules

This sample of participants consumed 0.2 servings more than the national median for fruit, and 0.4 servings less than the national median for vegetables based on MyPlate (33)