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The mucosal layer can also be attenuated as a result of reduced dietary fibre intake which encourages the growth of mucus-degrading species such as Bacteroides caccae and Akkermansia muciniphila (Desai et al

The most frequently reported adverse events in semaglutide studies included nausea, vomiting, and gastrointestinal discomfortnot respiratory symptoms

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What rarely gets explained is why any of this matters beyond digestion

Sun and Denko, 2014), or when mitochondrial respiration is impaired, the reductive carboxylation of glutamine-derived KG into citrate is promoted (Fendt et al, 2013) and supports lipogenesis (Metallo et al, 2011