10.1016/j.mvr.2020.104059 14 ChenW.JadhavV.TangJ.ZhangJ
Preclinical and clinical studies have demonstrated that bioactive compounds such as polyphenols, alkaloids, terpenoids, saponins, and flavonoids exert beneficial effects on AD-related pathways by reducing oxidative stress, suppressing neuroinflammation, preventing A aggregation, and modulating tau hyperphosphorylation (Liu et al., 2024)
The structure highlights the dual-agonist design: a GIP-based backbone (cyan/blue tones) with GLP-1 receptor-engaging modifications, and the C-20 fatty diacid chain extending from the acylated Lys20 that enables once-weekly dosing
Nature 546 , 168172 (2017)
3kn), lysosomes in SLCR-46.1::mCherryexpressing cells exhibited increased copper signals (Fig