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FDA briefing documents released before the meeting proposed the same conclusion for all seven peptides: do not add them

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Specific pathways affected include TGF-beta superfamily signaling, Wnt signaling, antioxidant defense (including superoxide dismutase, glutathione S-transferases, and thioredoxin reductase), and DNA repair mechanisms

Dysregulation of fat metabolism in mitochondria, possibly due to mitochondrial dysfunction, leads to a lack of fat oxidation, resulting in increased circulating fat levels and insulin resistance