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Science 361 , 842844 (2018)

Select your current weight 252lbs Weight you could lose (lbs): 50lbs Based on manufacturer trials studying the highest doses of Wegovy and Zepbound in non-diabetics with obesity, or with overweight plus a weight-related medical condition, when paired with diet and exercise changes (vs ~2-4% with diet and exercise alone)

9,12 Additionally, GLP-1RAs activate nitric oxide (NO) synthase expressed in Schlemms canal and the trabecular meshwork, increasing NO production to reduce trabecular meshwork contraction, improving aqueous outflow

When food remains in the stomach longer than usual, it can lead to feelings of fullness, abdominal distension, and bloating