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Hamedfam M, Sohrabi MR, Davallo M

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GLP-1 agonists are one of a few classes of diabetes medications proven to have cardiovascular, renal and mortality benefit in large-scale prospective randomised controlled trials

There is an urgent need for additional effective medicines, as the median survival rate is barely 35 years following diagnosis

The reduction of the NADP pool suggests that the electron influx into the NADP pool by metabolism more than compensates for the electron efflux to the anti-oxidant systems, and that glutathione reductase activity, catalysing the reduction of glutathione from NADPH, is limiting under the specific conditions of re-oxygenation after hypoxia