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Pep-21 treatment specifically silenced target miR-21 in B16 melanoma cells and M2 macrophages, reducing tumor cell migration and inhibiting tumor progression

What does exist falls into a few categories, none of which meets the bar that the word clinical ordinarily sets: Historical and patent-era work

Inhibition of lung tumorigenesis by metformin is associated with decreased plasma IGF-I and diminished receptor tyrosine kinase signaling

Of particular biochemical and physiological significance is the fact that the ALDH2*2 allele acts in a near dominant manner such that even heterozygotes have almost no detectable ALDH2 activity

10.1091/mbc.e12-12-0849 121 LeeS.-T.ChuK.JungK.-H.KimJ