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By means of dimethylated histone H3 K79, DOTL1 facilitates histone H4 acetylation, consequently regulating the binding of BRD4 to chromatin Moreover, inhibition of BRD4 activity was found to suppress proliferation in the majority of patients with chronic phase CML

doi: 10.3389/FENDO.2022.1033479 23 KoppKOGlotfeltyEJLiYGreigNH

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