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If reflux has been managed with medication, attempt a gradual step-down after 4 to 6 weeks at maintenance

The method of embodiment 128, wherein the viscosity modulating agent is silicon dioxide

This study aimed to compare the physiological roles of GIPR in the AP and hypothalamus by targeted regional KO of Gipr , using a floxed Gipr mouse model (Gipr fx/fx ) stereotactically injected with adeno-associated virus (AAV) encoding Cre-recombinase to generate mice with KO of Gipr in either the AP (Gipr AP-KO ) or hypothalamus (Gipr hypo-KO )

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