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145 ShibataS.WatanabeT.MatsumotoT.YunokiK.HorinouchiT.KirimotoH.et al (2022)

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A 2022 study in Frontiers in Pharmacology reported absorption, distribution, metabolism, and excretion data for the compound in rats and dogs, providing one of the first structured pharmacokinetic profiles in the peer-reviewed record [7]

Furthermore, H&E staining showed that compared to the aorta of normal aging mice, the aorta of mice treated with FOXO4-DRI was thinner, and the PWV value was lower in the ultrasound detection results, which means that the mice treated with FOXO4-DRI had better vascular elasticity and better vascular function than normal aging mice (Figures 1D,E)

Collagen may have formed, but the remodeling quality is poor