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According to Lillys release, the trial met its primary endpoint: participants titrating up to the highest orforglipron dose lost 27.3 lb (12.4%) of body weight at 72 weeks versus about 0.9% weight loss with placebo

Skipping doses or extending intervals beyond seven to ten days can reduce the medication's effectiveness, as the hormone concentration drops below therapeutic levels

You lost the weight now what

This is because discontinuing early can be viewed as non-adherence to the approved treatment plan

When throughput stalls, the most common response is often to invest in more space, more equipment, or more headcount