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Individuals who maintain adequate protein intake (1.2 to 1.6 grams per kilogram daily) tend to preserve more lean mass, which supports ongoing metabolic rate and continued fat loss

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There are also concerns about long-term benefits since upon cessation of semaglutide treatment, patients tend to regain a significant portion of the lost weight (138, 139), with reports that patients who underwent 68 weeks of treatment with semaglutide rapidly regained two-thirds of previously lost weight, and cardiometabolic measures reverted to baseline after 120 weeks following semaglutide withdrawal (139)