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Ferroptosis is characterized by increased levels of reactive oxygen species (ROS) and intracellular accumulation of labile ferrous ions (Fe 2+ ) that contribute to unrestrained lipid oxidation 43,44,45,46,47

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For example, cranberry extract reverses the high fat & high sucrose-induced gut microbiota alterations ( Akkermansia spp .) and improves metabolic syndrome (Table 2)