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This paper remains a landmark reference because it established that selective GHS-R1a agonism could achieve tissue-level anabolic outcomes comparable to less selective secretagogues while maintaining a more favorable endocrine side-effect profile in research models

Tando T, Hirayama A, Furukawa M, Sato Y, Kobayashi T, Funayama A, Kanaji A, Hao W, Watanabe R, Morita M, Oike T, Miyamoto K, Soga T, Nomura M, Yoshimura A, Tomita M, Matsumoto M, Nakamura M, Toyama Y, Miyamoto T (2016) Smad2/3 proteins are required for immobilization-induced skeletal muscle atrophy

doi: 10.1016/S0140-6736(14)60976-4 110 UmpierrezGTof PovedanoSPrez ManghiFShurzinskeLPechtnerV

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