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This study also showed a non-significant 17% reduction in albuminuria.67 The AWARD-7 study analyzed the efficacy of dulaglutide in patients with DM2 and moderate-severe CKD (mean eGFR 38 ml/min/1.73 m2)

The second-line ADMs included GLP1-R agonists, sulfonylureas, dipeptidyl peptidase-4 (DPP-4) inhibitors, or sodium-glucose cotransporter 2 (SGLT2) inhibitors

Room temperature better than hot: If cold doesnt appeal, at least avoid steaming hot

Because retatrutide activates three receptor types simultaneously, its gastrointestinal side effect profile can be more intense than single or dual agonists

Other weight loss drugs can act on more than one incretin receptor