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This led to improved insulin-stimulated glucose uptake and increased phosphorylation of downstream effectors such as glycogen synthase kinase 3 beta (GSK3) and glucose transporter 4 (GLUT4), particularly in hepatic and skeletal muscle tissues (38)

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e-Pub 2008

Although it seems counterintuitive that cardioinhibitory drugs such as beta-blockers would be used in cases of systolic dysfunction, clinical studies have shown conclusively that some specific beta-blockers improve cardiac function and reduce mortality