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GLP-1 receptor agonists do not directly address hormonal fluctuations or perimenopausal symptoms such as hot flushes, night sweats, or mood changes

This imbalance could lead to potential misestimation of GLP-1 RA effects when generalized to all KTRs with T2DM

As you might intuitively understand, gut hormones located in the gastrointestinal tract (GI tract), in particular, play central roles in regulating appetite and boosting metabolism: The feelings of appetite and satiety involve complex interactions between hormones from the gastrointestinal tract to the hypothalamus and subsequent feedback

The current American College of Rheumatology (ACR) criteria for FM diagnosis require the presence of chronic widespread pain for at least three months and assessment of patient symptom burden using the Widespread Pain Index (WPI) and Symptom Severity Scale (SSS)