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Rare but serious events such as pancreatitis (inflammation of the pancreas) or medullary thyroid cancer remain under surveillance because of animal toxicity signals

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High concentrations (2-3% or more)

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The high initial cost and technical complexity of the required equipment are significant barriers to large-scale industrial application ( 3.1.5 Subcritical water extraction method Also known as hot liquid or superheated water extraction ( Subcritical water extraction offers green, efficient technology for polyphenol extraction, but has several limitations