N Engl J Med 380:22952306
Robert Mllegger (Prsident) Univ.-Doz
Anand U, Yiangou Y, Akbar A, Quick T, MacQuillan A, Fox M et al (2018) Glucagon-like peptide 1 receptor (GLP-1R) expression by nerve fibres in inflammatory bowel disease and functional effects in cultured neurons
A year later Thorens published a second paper together with collaborators in Lausanne reporting on the cloning, sequencing and functional expression of the human GLP-1 receptor (Thorens, Porret, Bhler)
Starting at a lower dose (e.g., 2 mg instead of 4 mg) helps reduce gastrointestinal side effects such as nausea, vomiting, diarrhea, and constipation, which are more common with higher initial doses