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(NI) These neuropeptides are: Substance P (SP) that causes inflammation and pain Calcitonin Gene Related Peptide (CGRP) is a well-known driver of both migraine and clusters of symptoms including leg swelling (lymphedema) when in a histamine-mediated flare Vasoactive Intestinal Polypeptide (VIP) is a neuropeptide that functions as a neuromodulator and neurotransmitter

Also, ASNase consumption of Asp and glutamate could be supplemented by SLC1A3, thus eliminating the inhibitory effect of ASNase and promoting tumor development

10.1159/000192953 46 PugazhenthiS.NesterovaA.SableC.HeidenreichK

Clin Cosmet Investig Dermatol 8:371388

This peptide may lead to a disease-free life with future investigation by reducing senescent cell formation