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The peptide 'stays in the system' longer in terms of local dermal presence but shorter in terms of measurable plasma or whole-body distribution

A contraindication is a fundamental reason a person should not use the peptide at all due to a pre-existing condition (e.g., a copper disorder)

Facial flushing or warmth shortly after administration

Critics point out that the peptides for sale are often imperfect synthetics and are taken at doses much higher than any peptides in the body, raising the risk of allergic reactions and other harms

230 Webster and Maggio also noted that patients with large capacities under anesthesia were more likely to fail