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However, oral semaglutide requires strict administration protocols, it must be taken on an empty stomach with no more than 4 ounces of water, followed by a 30-minute wait before eating or drinking anything else

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When a blockage occurs, food, fluids, and gas cannot move normally through the intestines

Because each of those pathways ramps up its own physiological load, the documented protocol starts low and climbs in roughly four-week steps so the gut can adapt before the next increment lands