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Using advanced FACS sorting and low-input metabolic profiling , the team discovered that: Healthy HSCs are metabolically quiet , conserving energy and resources to protect their long-term function

We found that LOsG did not alter the mRNA levels of ER-stress responsive genes Xbp1 and BIP, inflammation-responsive genes IL6 and IL1, and hypoxia-response genes HIF1 and GAPDH compared with sham control mice (Fig

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