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The glutathione synthetase gene (symbol: GSS) is located on chromosome 20q11.22 and is composed of 15 exons that generate three alternatively spliced mRNAs, each of which encode the same 474 amino acid protein

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In the VM process, tumor cells and trophoblasts form vascular structures upon invasion, providing an additional blood supply different from endothelial-dependent vasculature (132, 133)