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There are reported cases of late recurrent melanomas associated with melanin pigmentation at the duodenal level, as well as an isolated case of panenteric melanosis secondary to a malignant melanoma confirmed by histopathology.9,10 In relation to malignant melanoma presentation sites, the rectum holds third place, after the skin and the eye

To investigate the transcriptional basis for the observed phenotypes, we performed transcriptomic analysis of liver tissue from 16h-fasted HFD-fed Gpr146 -/- and wild-type littermates

Upon activation by MenSCs, increased enrichment of 5-hmC and 5-mC in key enhancer regions leads to downregulation of the PI3K/AKT and RAF/ERK pathways, thereby inhibiting HCC cell proliferation and promoting apoptosis

Choi YH, Han H-K