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10.1016/j.theriogenology.2022.08.030 52 SarribleG

Catalytic cycle of human glutathione reductase near 1 resolution

Yes, dehydration is a common culprit

Conversion of the mitochondrial HMG-CoA, derived from leucine catabolism, to acetoacetyl-CoA and acetoacetate is catalyzed by HMG-CoA lyase (encoded by the HMGCL gene)