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437,438 Elevated serum levels of soluble intracellular adhesion molecule 1 (sICAM-1), indicative of increased vascular inflammation and/or endothelial dysfunction, have also been reported in PDPN

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[1] For constipation-related abdominal pain , increasing dietary fibre gradually, maintaining adequate hydration, and engaging in regular physical activity can be beneficial

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doi: 10.2337/dc12-2709