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While most people tolerate semaglutide injections well, a small percentage experience mild stinging or burning sensations lasting a few seconds after the needle enters the skin

(But hope springs eternal.) I enjoyed this relevant article about Professor Mike Snyder's quantified self project that just appeared in Stanford Magazine in Dec, 2021

Stiffness or pain in the joints

Expected Weight Loss Results- Clinical studies involving semaglutide show meaningful weight loss when paired with lifestyle changes

Clinicians should monitor body composition, adjust nutrition strategies, and encourage resistance training to preserve lean mass while maximizing cardiometabolic benefits