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Nuclear factor E2-related factor 2 (Nrf2), activated by ROS, protects against oxidative stress and chemically induced cell damage

doi: 10.1038/s41598-017-07215-7 83 GertzB.WongM.MartinL

The brands skincare and supplements, whose hero ingredient is the antioxidant glutathione, have gained a consumer following via licensed health care professionals and as testimonials on the products from biohackersa rising breed of wellness influencershave gone viral

Nevertheless, contemporary research has revealed that the administration of metformin can trigger ferroptosis by counteracting the generation of lipid ROS through autophagy inhibition ( Nuclear receptor coactivator 4 (NCOA4) is a discerning receptor that upholds iron homeostasis by binding to ferritin, conveying ferritin to lysosomes, and stimulating autophagic degradation

Methods Strains, plasmids and molecular biology methods All the strains and plasmids used in this study are listed in Table 1