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Numerous studies have demonstrated that the treatment with probiotics, prebiotics, and synbiotics that affect the gut microbiota, may reduce insulin resistance and hepatic inflammation (Figure 13)

The aqueous extract of Ulva intestinalis also increased the levels of chlorophyll a and b in parsley seedlings 47

Additionally, a prespecified exploratory analysis showed 60% of participants on the highest, 15-mg dose of tirzepatide (Eli Lilly) achieved a composite endpoint of an HbA1c of 6.5% or lower and weight loss of 10% or greater with no reports of severe hypoglycemia, compared with 22% of participants assigned 1 mg semaglutide (Ozempic, Novo Nordisk)

Early clinical trials suggest it may represent a groundbreaking advancement in obesity and diabetes treatment

Efficacy and safety of retatrutide in people with type 2 diabetes: a multicentre, randomised, double-blind, placebo-controlled, phase 1b trial