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A decline in ACE2 function in aged individuals, coupled with the age-associated deterioration in mitochondrial functions results in chronic metabolic disorders like diabetes or cancer, and predisposes the host for increased susceptibility to infection, vulnerability to health complications, and intensifies the risk of mortality 163

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The TC (Figure 6D) and TG (Figure 6E) contents in serum of rats in T2DM + RYGB and T2DM + EX-4 groups significantly reduced after surgery, while those in T2DM and T2DM + sham groups increased steadily