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As fat tissue grows and more NNMT is produced, higher amounts of hormones and pro-inflammatory signals are produced that are responsible for weight gain and other chronic diseases such as type 2 diabetes and cardiovascular disease. NNMT is responsible for converting nicotinamide (NA) into 1-methylnicotinamide (1-MNA), which takes it out of the NAD salvage pathway (see the diagram below)

Telegram post, January 2026 Cases like these are especially troubling given reports from a Texas lab that a third of the peptide samples they test fail identity, purity, or quantity checks

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A single 3-hour infusion of 750 mg increased blood NAD+ approximately 398% above baseline (Grant et al., 2019)